Synthesis of 3-Substituted Pyrrolidines via Palladium-Catalyzed Hydroarylation

Palladium-catalyzed desulfitative hydroarylation of alkynes with sodium sulfinates.

A palladium-catalyzed desulfitative hydroarylation of alkynes with aryl sulfinic acid sodium salts is described. The reaction showed good regio- and stereoselectivity, and afforded the hydroarylation products in good yields. Various functional groups were well tolerated under the optimized reaction conditions.

Synthesis of heterocycles via palladium-catalyzed carbonylations.

Palladium - Catalyzed Intramolecular C – H Difluoroalkyation : The Synthesis of Substituted 3 , 3 - Difluoro - 2 - oxindoles

The synthesis of 3,3-difluoro-2-oxindoles through a robust and efficient palladium-catalyzed C–H difluoroalkylation is described. This process generates a broad range of difluorooxindoles from readily prepared starting materials. The use of BrettPhos as the ligand was crucial for high efficiency. Preliminary mechanistic studies suggest that oxidative addition is the rate-determining step for th...

Palladium-catalyzed asymmetric hydrogenation of 3-phthalimido substituted quinolines.

Homogeneous Pd-catalyzed asymmetric hydrogenation of 3-phthalimido substituted quinolines was successfully developed, providing facile access to chiral substituted tetrahydroquinolines bearing two contiguous stereogenic centers with up to 90% ee.

The palladium-catalyzed hydroarylation and hydrovinylation of carbon-carbon multiple bonds: new perspectives in organic synthesis

Th is r e a c t i o n , t h e Heck's r e a c t i o n , has been t h e s u b j e c t o f severa l mechan is t i c and s y n t h e t i c s tud ies and has a wide f i e l d o f a p p l i c a t i o n i n o rgan ic syn thes is .1 o -A lky lpa l l ad ium complexes ( l ) , however, under s u i t a b l e r e a c t i o n cond i t i ons , a re ab le t o undergo a carbon-pal lad ium bond f i s s i o n s u...